ABSTRACT
RESUMO Objetivo: analisar prevalência de Hipertensão Arterial Sistêmica e Diabetes mellitus nos indígenas aldeados associadas à etnia e descrever a frequência de atendimento/diagnóstico segundo categoria profissional. Método: estudo epidemiológico, descritivo, realizado com dados de Hipertensão Arterial Sistêmica e Diabetes mellitus produzidos nos Distritos Sanitários Especiais Indígenas, do Pará, entre 2013-2017, obtidos do Sistema de Informações da Atenção à Saúde Indígena. Para análise, agrupou-se as morbidades e utilizou-se o Qui-quadrado de Pearson, p≤0,05. Resultados: foram estudados 624 casos de Hipertensão Arterial Sistêmica e 108 casos de Diabetes mellitus, identificando-se maior acometimento de mulheres. A etnia Munduruku apresentou maior prevalência de Hipertensão Arterial Sistêmica (35,0%; n=219) e Diabetes mellitus (23,1%; n=25). Observou-se participação expressiva da equipe de enfermagem no atendimento aos indígenas. Conclusão: A prevalência identificada pode ser atribuída à acelerada transição nutricional e mudanças nos hábitos de vida. Tais achados são importantes para assistência de enfermagem qualificada e culturalmente significada.
RESUMEN Objetivo: analizar la prevalencia de Hipertensión Arterial Sistémica y de la Diabetes mellitus en pobladores indígenas asociada a la etnia y describir la frecuencia de atención/diagnóstico según la categoría profesional. Método: estudio epidemiológico y descriptivo, realizado con datos de hipertensión arterial sistémica y diabetes mellitus producidos en los Distritos Especiales de Salud Indígena del Estado de Pará, entre 2013-2017, obtenidos del Sistema de Información de Atención a la Salud Indígena. Para el análisis, se agruparon las morbilidades y se utilizó la prueba de chi-cuadrado de Pearson, p≤0,05. Resultados: Se estudiaron 624 casos de Hipertensión Arterial Sistémica y 108 casos de Diabetes mellitus, identificando una mayor afectación de las mujeres. El grupo étnico Munduruku mostró una mayor prevalencia de hipertensión sistémica (35,0%; n=219) y de diabetes mellitus (23,1%; n=25). Se observó la participación expresiva del equipo de enfermería en el cuidado de los indígenas. Conclusión: La prevalencia identificada puede atribuirse a la transición nutricional acelerada y a los cambios en los hábitos de vida. Estos resultados son importantes para una atención de enfermería cualificada y culturalmente significativa.
ABSTRACT Objective: to analyze the prevalence of systemic hypertension and diabetes mellitus among indigenous villagers associated with ethnicity and describe the frequency of care/diagnosis according to professional category. Method: epidemiological and descriptive study, carried out with data on Systemic Hypertension and Diabetes Mellitus produced in the Distritos Sanitários Especiais Indígenas (Special Indigenous Health Districts of Pará), between 2013-2017, obtained from the Sistema de Informações da Atenção à Saúde Indígena (Indigenous Health Care Information System). For analysis, the morbidities were grouped, and Pearson's Chi-square was used, p≤0.05. Results: 624 cases of Systemic Arterial Hypertension and 108 cases of Diabetes mellitus were studied, identifying a greater involvement of women. The Munduruku ethnic group showed a higher prevalence of systemic hypertension (35.0%; n=219) and diabetes mellitus (23.1%; n=25). It was observed expressive participation of the nursing team in the care of indigenous peoples. Conclusion: The identified prevalence can be attributed to the accelerated nutritional transition and changes in lifestyle habits. Such findings are important for qualified and culturally meaningful nursing care.
ABSTRACT
Glycosylation of the Fc region of IgG has a profound impact on the safety and clinical efficacy of therapeutic antibodies. While the biantennary complex-type oligosaccharide attached to Asn297 of the Fc is essential for antibody effector functions, fucose and outer-arm sugars attached to the core heptasaccharide that generate structural heterogeneity (glycoforms) exhibit unique biological activities. Hence, efficient and quantitative glycan analysis techniques have been increasingly important for the development and quality control of therapeutic antibodies, and glycan profiles of the Fc are recognized as critical quality attributes. In the past decade our understanding of the influence of glycosylation on the structure/function of IgG-Fc has grown rapidly through X-ray crystallographic and nuclear magnetic resonance studies, which provides possibilities for the design of novel antibody therapeutics. Furthermore, the chemoenzymatic glycoengineering approach using endoglycosidase-based glycosynthases may facilitate the development of homogeneous IgG glycoforms with desirable functionality as next-generation therapeutic antibodies. Thus, the Fc glycans are fertile ground for the improvement of the safety, functionality, and efficacy of therapeutic IgG antibodies in the era of precision medicine.
Subject(s)
Animals , Humans , Antibodies, Monoclonal , Pharmacokinetics , Therapeutic Uses , Glycosylation , Immunoglobulin G , Chemistry , Metabolism , Protein Engineering , Methods , Receptors, Fc , Chemistry , Metabolism , Treatment OutcomeABSTRACT
<p>Chylorrhea is a rare complication after cardiothoracic surgery, occurring in 0.5-2% of patients. It is extremely rare after coronary artery bypass grafting. The initial management of chylorrhea is conservative, but if it is unsuccessful, surgical intervention is indicated. Recently, some cases treated with octreotide have been reported. We report two cases of chylorrhea after internal thoracic artery harvest treated with octreotide.</p>
ABSTRACT
<i>Aspergillus </i>pseudoaneurysm of the ascending aorta is rare in patients who have undergone coronary artery bypass graft surgery (CABG), and there are few cases reports of patients with AIDS, or after transplantation. A 76-year-old man underwent CABG due to unstable angina in 2002 ; in 2005 and 2006, he suffered 3 episodes of pseudoaneurysm formation in the ascending aorta. The aneurysm was resected and the defect was repaired with a Dacron patch twice. Finally, aortic root replacement with the modified Bentall technique was performed, but pathological examination of the wall of the pseudoaneurysm showed <i>Aspergillus</i>. On day 13, the <i>Aspergillus </i>infection developed into septicemia, and he died.
ABSTRACT
<i>Aspergillus </i>pseudoaneurysm of the ascending aorta is rare in patients who have undergone coronary artery bypass graft surgery (CABG), and there are few cases reports of patients with AIDS, or after transplantation. A 76-year-old man underwent CABG due to unstable angina in 2002 ; in 2005 and 2006, he suffered 3 episodes of pseudoaneurysm formation in the ascending aorta. The aneurysm was resected and the defect was repaired with a Dacron patch twice. Finally, aortic root replacement with the modified Bentall technique was performed, but pathological examination of the wall of the pseudoaneurysm showed <i>Aspergillus</i>. On day 13, the <i>Aspergillus </i>infection developed into septicemia, and he died.